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Journal article

110. Assessing the Manufacturability and Critical Quality Attribute Profiles of Anti-IL-8 Immunoglobulin G Mutant Variants

Published on
7/11/2024
Research area:
Bioconjugation chemistry
Research area:
Other
Research area:
Medicinal Chemistry
Journal article

109. Core Modifications of GSK3335103 toward Orally Bioavailable αvβ6 Inhibitors with Improved Synthetic Tractability

Published on
17/10/2024
Research area:
Medicinal Chemistry
Research area:
Other
Research area:
Chemical Biology
Journal article

108. Reactivity Profiling for High-Yielding Ynamine-Tagged Oligonucleotide Click Chemistry Bioconjugations

Published on
10/10/2024
Research area:
Bioconjugation chemistry
Research area:
Chemical Biology
Research area:
Other
Journal article

107. Biocatalytic Synthesis of Ribonucleoside Analogues Using Nucleoside Transglycosylase-2

Published on
1/10/2024
Research area:
Medicinal Chemistry
Research area:
Modulation of RNA splicing
Research area:
Other
Research area:
Chemical probe design
Journal article

106. Gram-Scale Enzymatic Synthesis of 2ʹ-Deoxyribonucleoside Analogues Using Nucleoside Transglycosylase-2

Published on
27/8/2024
Research area:
Other
Journal article

105. A First Insight into the Developability of an Immunoglobulin G3: A Combined Computational and Experimental Approach

Published on
15/7/2024
Research area:
Bioconjugation chemistry
Research area:
Medicinal Chemistry
Journal article

104. A framework for the biophysical screening of antibody mutations targeting solvent-accessible hydrophobic and electrostatic patches for enhanced viscosity profiles

Published on
23/5/2024
Research area:
Bioconjugation chemistry
Research area:
Medicinal Chemistry
Research area:
Chemical probe design
Journal article

103. Mechanistic Basis of the Cu(OAc)2 Catalyzed Azide-Ynamine (3 + 2) Cycloaddition Reaction

Published on
7/5/2024
Research area:
Bioconjugation chemistry
Journal article

102. Innovative, combinatorial and high-throughput approaches to degrader synthesis

Published on
10/4/2024
Research area:
Chemical probe design
Research area:
Medicinal Chemistry
Research area:
Bioconjugation chemistry
Journal article

101. 2′-19F labelling of ribose in RNAs: a tool to analyse RNA/protein interactions by NMR in physiological conditions

Published on
14/2/2024
Research area:
Other
Journal article

100. Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs

Published on
7/11/2023
Research area:
Medicinal Chemistry
Journal article

99. Antibody-Proteolysis Targeting Chimera Conjugate Enables Selective Degradation of Receptor-Interacting Serine/Threonine-Protein Kinase 2 in HER2+ Cell Lines

Published on
2/11/2023
Research area:
Bioconjugation chemistry
Research area:
Medicinal Chemistry
Journal article

98. Glutathione Mediates Control of Dual Differential Bio-orthogonal Labelling of Biomolecules

Published on
31/10/2023
Research area:
Bioconjugation chemistry
Research area:
Chemical probe design
Journal article

97. Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome

Published on
17/1/2023
Research area:
Chemical probe design
Research area:
Medicinal Chemistry
Journal article

96. Fluorous-Directed Assembly of DNA Origami Nanostructures

Published on
20/12/2022
Research area:
Bioconjugation chemistry
Research area:
Chemical probe design
Journal article

95. Surface Passivation with a Perfluoroalkane Brush Improves the Precision of Single-Molecule Measurements

Published on
28/10/2022
Research area:
Chemical probe design
Journal article

94. Oligonucleotide-Recognizing Topoisomerase Inhibitors (OTIs): Precision Gene Editors for Neurodegenerative Diseases?

Published on
29/9/2022
Research area:
Chemical probe design
Journal article

93. Biophysical characterisation of the Bcl-x pre-mRNA and binding specificity of the ellipticine derivative GQC-05: Implication for alternative splicing regulation

Published on
17/8/2022
Research area:
Chemical probe design
Journal article

92. Biosynthesis of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis

Published on
18/7/2022
Research area:
Chemical probe design
Journal article

91. A Chemo- and Regioselective Tandem [3 + 2]Heteroannulation Strategy for Carbazole Synthesis: Combining Two Mechanistically Distinct Bond-Forming Processes

Published on
18/3/2022
Research area:
Chemical probe design
Journal article

90. Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites

Published on
6/8/2021
Research area:
Chemical probe design
Journal article

89. A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications

Published on
27/5/2021
Research area:
Chemical probe design
Journal article

87. Contra-thermodynamic E → Z isomerization of cinnamamides via selective energy transfer catalysis

Published on
18/12/2020
Research area:
Chemical probe design
Journal article

88. Glasgow Early Treatment Arm Favirpiravir (GETAFIX) for adults with early stage COVID-19: A structured summary of a study protocol for a randomised controlled trial

Published on
19/11/2020
Research area:
Chemical probe design
Journal article

83. Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity

Published on
1/10/2020
Research area:
Bioconjugation chemistry
Journal article

85. Identification of 2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-N-phenylpropanamides as a novel class of potent DprE1 inhibitors

Published on
15/6/2020
Research area:
Chemical probe design
Journal article

86. Biocatalytic Alkylation Cascades: Recent Advances and Future Opportunities for Late-Stage Functionalization

Published on
27/5/2020
Research area:
Chemical probe design
Journal article

84. Two-dimensional infrared spectroscopy: an emerging analytical tool?

Published on
10/2/2020
Research area:
Chemical probe design
Journal article

80. S-Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C-Alkylation

Published on
1/10/2019
Research area:
Modulation of RNA splicing
Journal article

81. An investigation of targeted inhibition of transcription factor activity with pyrrole imidazole polyamide (PA) in chronic myeloid leukemia (CML) blast crisis cells

Published on
15/9/2019
Research area:
Modulation of RNA splicing
Journal article

78. Splice-switching small molecules: A new therapeutic approach to modulate gene expression

Published on
1/9/2019
Research area:
Modulation of RNA splicing
Journal article

82. Molecular Construction of Sulfonamide Antisense Oligonucleotides

Published on
5/8/2019
Research area:
Transcriptional regulation
Journal article

79. Whisky tasting using a bimetallic nanoplasmonic tongue

Published on
3/7/2019
Research area:
Transcriptional regulation
Journal article

77. Sequence-Selective Minor Groove Recognition of a DNA Duplex Containing Synthetic Genetic Components

Published on
22/5/2019
Research area:
Bioconjugation chemistry
Journal article

76. PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding

Published on
26/2/2019
Research area:
Modulation of RNA splicing
Journal article

75. Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues

Published on
8/11/2018
Research area:
Modulation of RNA splicing
Journal article

73. A flow platform for degradation-free CuAAC bioconjugation

Published on
1/10/2018
Research area:
Transcriptional regulation
Journal article

74. Organic Semiconductor Laser Platform for the Detection of DNA by AgNP Plasmonic Enhancement

Published on
18/9/2018
Research area:
Bioconjugation chemistry
Journal article

70. Effect of oligomer length on vibrational coupling and energy relaxation in double-stranded DNA

Published on
17/8/2018
Research area:
Bioconjugation chemistry
Journal article

72. The mechanisms of a mammalian splicing enhancer

Published on
16/3/2018
Research area:
Transcriptional regulation
Journal article

69. Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells

Published on
1/3/2018
Research area:
Transcriptional regulation
Journal article

71. Oxidative β-C–H sulfonylation of cyclic amines

Published on
22/1/2018
Research area:
Transcriptional regulation
Journal article

68. Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides

Published on
29/11/2017
Research area:
Modulation of RNA splicing
Journal article

67. Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

Published on
16/11/2017
Research area:
Modulation of RNA splicing
Book chapter

4. Minor Groove Binders as Therapeutic Agents

Published on
29/7/2017
Research area:
Transcriptional regulation
Journal article

66. Modular, Step-Efficient Palladium-Catalyzed Cross-Coupling Strategy To Access C6-Heteroaryl 2-Aminopurine Ribonucleosides

Published on
6/7/2017
Research area:
Bioconjugation chemistry
Journal article

62. A Tandem Enzymatic sp2-C-Methylation Process: Coupling in Situ S-Adenosyl-l-Methionine Formation with Methyl Transfer (ChemBioChem 11/2017)

Published on
15/5/2017
Research area:
Chemical probe design
Journal article

65. Synthetic biological approaches for RNA labelling and imaging: design principles and future opportunities

Published on
8/5/2017
Research area:
Bioconjugation chemistry
Journal article

64. Strategy for Conditional Orthogonal Sequential CuAAC Reactions Using a Protected Aromatic Ynamine

Published on
28/4/2017
Research area:
Chemical probe design
Journal article

63. Ultrafast 2D-IR and optical Kerr effect spectroscopy reveal the impact of duplex melting on the structural dynamics of DNA

Published on
6/4/2017
Research area:
Chemical probe design
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Eilidh McKay

Harry Palmer

Helena Keaveney

Ivan Yankov

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Lauren Paszczuk

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