Bioconjugate
Design
Introduction
Bio-orthogonal chemistry enables the reaction of two reagents to occur in the presence of a myriad of other reactive groups present in the cellular environment. We are developing new bio-orthogonal reactions that are fast, produce a single product (i.e., no regioisomers) and can be used in the presence of other bio-orthogonal reagents. These reactions are being used to prepare protein and nucleic acid-based bioconjugates and as chemical probes in cell biology.
Related Publications
114.
Quantifying antibody binding: techniques and therapeutic implications
111.
Biocatalytic Synthesis of Ribonucleoside Analogues Using Nucleoside Transglycosylase-2
109.
Assessing the Manufacturability and Critical Quality Attribute Profiles of Anti-IL-8 Immunoglobulin G Mutant Variants
107.
Reactivity Profiling for High-Yielding Ynamine-Tagged Oligonucleotide Click Chemistry Bioconjugations
105.
A First Insight into the Developability of an Immunoglobulin G3: A Combined Computational and Experimental Approach
103.
Mechanistic Basis of the Cu(OAc)2 Catalyzed Azide-Ynamine (3 + 2) Cycloaddition Reaction
102.
Innovative, combinatorial and high-throughput approaches to degrader synthesis
99.
Antibody-Proteolysis Targeting Chimera Conjugate Enables Selective Degradation of Receptor-Interacting Serine/Threonine-Protein Kinase 2 in HER2+ Cell Lines
98.
Glutathione Mediates Control of Dual Differential Bio-orthogonal Labelling of Biomolecules
97.
Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome
96.
Fluorous-Directed Assembly of DNA Origami Nanostructures
95.
Surface Passivation with a Perfluoroalkane Brush Improves the Precision of Single-Molecule Measurements
94.
Oligonucleotide-Recognizing Topoisomerase Inhibitors (OTIs): Precision Gene Editors for Neurodegenerative Diseases?
93.
Biophysical characterisation of the Bcl-x pre-mRNA and binding specificity of the ellipticine derivative GQC-05: Implication for alternative splicing regulation
91.
A Chemo- and Regioselective Tandem [3 + 2]Heteroannulation Strategy for Carbazole Synthesis: Combining Two Mechanistically Distinct Bond-Forming Processes
90.
Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites
92.
Biosynthesis of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis
89.
A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications
87.
Contra-thermodynamic E → Z isomerization of cinnamamides via selective energy transfer catalysis