Burley Labs https://burleylabs.co.uk/ Collaborate to innovate Fri, 27 Mar 2026 10:05:30 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://burleylabs.co.uk/wp-content/uploads/2026/03/cropped-Untitled-50-x-50-px-32x32.webp Burley Labs https://burleylabs.co.uk/ 32 32 Split-APEX implicates splicing factor SRSF1 and splicing helicases in ribosomal biogenesis https://burleylabs.co.uk/publications/split-apex-implicates-splicing-factor-srsf1-and-splicing-helicases-in-ribosomal-biogenesis/ Tue, 27 Jan 2026 16:36:55 +0000 http://burleylabs.co.uk/?p=3853 The post Split-APEX implicates splicing factor SRSF1 and splicing helicases in ribosomal biogenesis appeared first on Burley Labs.

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]]> Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers https://burleylabs.co.uk/publications/antibody-drug-conjugates-as-multimodal-therapies-against-hard-to-treat-cancers/ Tue, 27 Jan 2026 16:35:00 +0000 http://burleylabs.co.uk/?p=3850 The post Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers appeared first on Burley Labs.

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]]> October PhD position 2026 https://burleylabs.co.uk/publications/october-phd-position-2026/ Fri, 28 Nov 2025 12:58:54 +0000 http://burleylabs.co.uk/?p=1992 We have a 4-year PhD chemical biology project available for October 2026. The focus of this project is to determine the molecular functions of Base-J, a modified nucleotide found in Trypanosomatid genomes.

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]]> October-December 2025 https://burleylabs.co.uk/publications/october-december-2025/ Fri, 28 Nov 2025 12:58:34 +0000 http://burleylabs.co.uk/?p=1990 In October we welcomed our other first year PhD, Theo. Lucy presented a poster at ChemBioParis2025 and at Charles River Laboratories PhD poster competition in Cambridge.

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]]> November 2025 PhD position https://burleylabs.co.uk/publications/november-2025-phd-position/ Fri, 28 Nov 2025 12:38:49 +0000 http://burleylabs.co.uk/?p=1938 We have a 4-year industrial studentship available for an October 2026 start (https://lnkd.in/eFTbqkbu). This project is in collaboration with GSK, and is aimed at establishing new synthetic methodology to access novel modifications for therapeutic oligonucleotides.

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We have a 4-year industrial studentship available for an October 2026 start (https://lnkd.in/eFTbqkbu). This project is in collaboration with GSK, and is aimed at establishing new synthetic methodology to access novel modifications for therapeutic oligonucleotides. In collaboration with David Palmer, the student will establish a data analytics platform to eventually predict their binding properties using biophysical and computational instrumentation established in the Department of Pure and Applied Chemistry. Finally, the student will collaboration with the Haiyan Zhou group to evaluate the biological activity of these therapeutic oligonucleotides in cell and mouse models. The deadline for applications is 23 January, 2026, but interviews will take place as suitable applications are received.

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]]> Long-Range Allosteric Modulation of DNA Duplex Dynamics Induced by Pyrrole-Imidazole Polyamide Binding https://burleylabs.co.uk/publications/117-long-range-allosteric-modulation-of-dna-duplex-dynamics-induced-by-pyrrole-imidazole-polyamide-binding/ Mon, 28 Jul 2025 11:32:33 +0000 http://burleylabs.co.uk/?p=1452 117.

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]]> Chemoselective Difluoromethylation of Nucleosides https://burleylabs.co.uk/publications/116-chemoselective-difluoromethylation-of-nucleosides/ Tue, 17 Jun 2025 11:33:27 +0000 http://burleylabs.co.uk/?p=1454 116.

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]]> Preparation of nucleoside analogues: opportunities for innovation at the interface of synthetic chemistry and biocatalysis https://burleylabs.co.uk/publications/115-preparation-of-nucleoside-analogues-opportunities-for-innovation-at-the-interface-of-synthetic-chemistry-and-biocatalysis/ Thu, 05 Jun 2025 11:33:44 +0000 http://burleylabs.co.uk/?p=1456 Nucleoside analogues are used throughout nature. They comprise the key building blocks in nucleic acids and in second messenger small molecules. Additionally, modifications to the sugar and nucleobase moieties have been a pervasive feature in the development of nucleoside therapeutics. Despite their ubiquity across all facets of medicinal chemistry and biology, methods to prepare nucleoside analogues are challenging. Recent innovations in the chemical and biocatalytic syntheses of nucleosides offer new opportunities for the step-efficient and environmentally sustainable preparation of these high value analogues. This perspective outlines the key innovations between 2020–2025 and presents opportunities for further integration of these strategies to prepare nucleoside analogues not possible using each of these approaches in isolation.

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]]> Quantifying antibody binding: techniques and therapeutic implications https://burleylabs.co.uk/publications/114-quantifying-antibody-binding-techniques-and-therapeutic-implications/ Sun, 16 Feb 2025 11:34:15 +0000 http://burleylabs.co.uk/?p=1458 114.

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]]> Factors to Consider for Synthesis in 1536-Well Plates─An Amide Coupling Case Study for PROTAC Synthesis https://burleylabs.co.uk/publications/113-factors-to-consider-for-synthesis-in-1536-well-plates%e2%94%80an-amide-coupling-case-study-for-protac-synthesis/ Sun, 02 Feb 2025 11:34:31 +0000 http://burleylabs.co.uk/?p=1460 113.

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