Nucleic Acid Nanotechnology

DNA has considerable potential as a template to assemble functional materials for diagnostic and photonic device applications. Our aim is to develop enabling methodology that interfaces light-harvesting and optical materials with DNA nanostructures with our long-term objective being to incorporate these assemblies into device platforms.

DNA is a naturally-occurring molecule that is used by nature to store all of the instructions required for the functioning of a living being. DNA achieves this function by storing information using a genetic code made up of four building blocks (A, G, C, and T). DNA can also be used for functions other than the storage of genetic information in living systems.
We are developing new approaches for the construction of electronic, diagnostic and medical devices based on the genetic code of DNA. Current efforts are focused on developing plasmonic waveguides, DNA diagnostic and medical sensing devices.
Relevant Publications Collaboration
Berti, L., Burley, G. A., "Nucleic acid and nucleotide-mediated synthesis of inorganic nanoparticles" Nature Nanotechnology, 2008, 3, 81-87. [link]

Su, W., Schuster, M., Bagshaw, C.R., Rant, U., Burley, G.A. "Site-specific assembly of DNA-based photonic wires by using programmable polyamides" Angewandte Chemie International Edition, 2011, 50, 2712-2715. [link]

Su, W., Bonnard, V.B., Burley, G.A. "DNA-templated photonic arrays and assemblies: Design principles and future opportunities"  Chemistry - A European Journal, 2011, 17, 7982-7991.[link]

Krpetic, Z., Singh, I., Su, W., Guerrini, L., Faulds, K., Burley, G.A., Graham, D. "Directed Assembly of DNA-Functionalized Gold Nanoparticles Using Pyrrole-Imidazole Polyamides" Journal of the American Chemical Society, 2012, 134, 8536-8539. [link]

Dr Alasdair Clark
Prof. Richard Cogdell
Prof. Duncan Graham
Institute of Photonics
further reading
General nanotechnology
General nanotechnology (2)
Prof. Nadrian Seeman